Higuchi connors phase solubility techniques
The quantification of a natural bioactive compound, pterostilbene (PTT), in commercial capsule dosage form, solubility, and stability samples was carried out using a rapid and sensitive high-performance liquid chromatography (HPLC) approach. PTT was quantified on a Nucleodur (150 mm × 4.6 mm) RP C18 column with a particle size of 5 …Phase solubility studies [19]. Phase solubility studies were performed according to the method suggest by Higuchi and Connors. An excess amount of ...The phase solubility diagrams of DMY with α-CD, β-CD, γ-CD, HP-β-CD, and DM-β-CD obtained in water at 25 °C are shown in Fig. 1.The aqueous solubility of DMY increased linearly (r 2 ≥ 0.99) with increasing CD concentration at a range of 0–10 mM. All phase diagrams belonged to A L-type according to Higuchi and Connors, suggesting …
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K. A. Connors and J. J. Lipari. Effect of cycloamyloses on apparent dissociation constants of carboxylic acids and phenols: Equilibrium analytical selectivity induced by complex formation. J.Phase Solubility Analysis. C R C Critical Reviews in Analytical Chemistry: Vol. 1, No. 2, pp. 193-215. ... Takeru Higuchi . Pages 193-215 Published online: 18 Feb 2008.Phase solubility study. The effect of complexation with βCD and HPβCD on the solubility of GA was assessed. The phase solubility diagram was used in order to evaluate the solubility of GA in the presence of CDs according to Higuchi & Connors . The amount of GA was kept in excess and mixed up with different concentrations of βCD (0–16 mM ...
Feb 28, 2023 · According to the classification of the phase solubility diagram of Higuchi and Connors (Eq. 1), the HO-AAVPA solubility profiles correspond to the type A L phase diagrams, which support the ... Types of phase-solubility diagrams according to Higuchi and Connors showing how the total drug solubility changes with increasing CD concentration. A-type diagrams are formed when the drug/CD complex is soluble in the aqueous complexation media and they are usually associated with the water-soluble CD derivatives.T. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212. has been cited by the following article: TITLE: Binary and Ternary Complexes of Arteether β-CD - Characterization, Molecular Modeling and in Vivo StudiesThe present study was aimed to formulate the solid dispersion incorporated microcapsule to improve the dissolution rate and half life of pioglitazone hydrochloride. The solvent evaporation method was used to formulate the solid dispersion resulted increased dissolution rate, bioavailability and stability. Finally increase the half life of the ...
Characterization of ternary complexes of meloxicam-HPβCD and PVP or L-arginine prepared by the spray-drying techniqueTernary complexes of meloxicam (ME) (a poorly water soluble anti-inflammatory drug) with hydroxypropyl-β-cyclodextrin (HPβCD) and either a hydrophilic polymer, namely, polyvinyl pyrrolidone (PVP) or a basic amino acid …Phase solubility studies of BDQ in the presence of SBE-β-CD was performed according to the method described by Higuchi and Connors [30] and previously ...T. Higuchi and K. A. Connors. Phase solubility techniques. Adv. Anal. Chem. Instrum. 4:117–212 (1965). ... In S. Yalkowsky (ed.), Techniques of Solubilization of Drugs, Marcel Dekker, New York, 1981, pp. 135–149. Google Scholar T. Higuchi and H. Kristiansen. Binding specificity between small organic solutes in aqueous solution ... ….
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For this purpose, the phase solubility of curcumin was assessed using Higuchi and Connors. ... Phase-solubility techniques. Advances in. Analytical Chemistry and Instrumentation, 4 (2), 117–212.The Higuchi–Connors phase-solubility method8) is very often used to ... The phase-distribution method is a very versatile and fast method and has the advantage, ...
The Higuchi–Connors phase-solubility method8) is very often used to determine K 1:1, as a part of a formulation study. This method is based on the effect of a complex forming lig-and, e.g. CD, on the solubility of the drug. The intrinsic solu-bility (S 0) and the slope of the phase-solubility diagram are then used to calculate K 1:1In present work, phase solubility analysis were conducted for studying the solubility of terpineol, a natural flavor compound with antifungal and disinfectant …Solubility method (phase solubility analysis) Solubility studies were carried out according to the method reported by Higuchi and Connors (1965) . Excess amounts of DAN were added to aqueous solutions (pH 6.2 ± 0.1) containing increasing concentrations of BCD (2.0 × 10 −3 to 14.0 × 10 −2 M) and the samples were shaken on a rotary shaker ...
k state basketball schedule women's Phase Solubility Studies. These studies were performed to select the stoichiometry of FLF - β-CD and FLF - β-CD - Soluplus® using the described method by Higuchi-Connors . Briefly, different concentrations of β-CD solutions (2–12 mM) were prepared, and an excess quantity of FLF was added to the solution.The apparent stability constant of the KET- BCD complex, assuming 1:1 stoichiometry, were calculated from the slope of the initial straight portion of the phase solubility diagrams as KH = slope/S0(1 - slope) where So is the solubility of the pure drug (Higuchi and Connors, 1965). All the data are the average of three determinations. 2.3. performancemanagementjayhawk meaning 7 Ağu 2017 ... All other reagents used are of analytical grade. Phase solubility study (Higuchi Connors method). Phase solubility studies were performed ... sheetz pregnancy test The objective of the present investigation was to formulation development of solid dispersion of voriconazole using hot-melt, solvent evaporation and combination of these two methods together with Gelucire® 44/14, polaxamer 188 and polyvinyl pyrrolidone (PVP) K30 and the different characteristics like drug content analysis and in vitro release of the solid dispersions were investigated. when does the kansas jayhawks play againdsw degree social workyakuza 0 leisure king properties Aug 8, 2022 · Stoichiometry and constant formation of the inclusion complex 1H 4 MGF:1βCD by Higuchi–Connors method. The method of Higuchi and Connors proposes that to determine the inclusion constant of a formed complex 1H 4 MGF:1βCD, the phase-solubility diagram, ([H 4 MGF] = f([βCD])) of saturated solutions in mangiferin must show a linear trend and then equation relates the slope (α) and intercept ... Phase solubility studies. The phase solubility studies were performed using Higuchi and Connors method (Higuchi & Connors, 1965). Briefly, different concentrations of β-CD (0, 2, 6, 8, 10 and 20 mM) were prepared in deionised water in glass capped vials. To each vial 1 mg CUR was added. kansas st football score The phase solubility investigation was carried out according to Higuchi and Connors approach . Excess DoN was added to distilled water containing various concentrations of Kollidon VA 64 in 20-mL capped bottles, stirred for 48 h at 25 and °C on magnetic stirrer, filtered, and spectrophotometrically analyzed at 283 nm using a double … worcester commuter rail stationku football stadium mapkuva tonkor build All experiments were repeated three times. According to the linear part of the phase solubility curve, the stability constant (Kc) was calculated using the Higuchi-Connors equation. (1) K c = S l o p e S 0 × (1-S l o p e) S 0: the solubility of NAR without β-CD. The solubilizing efficiency of β-CD was evaluated by the complexation efficiency ...24 Oca 2006 ... reported by Higuchi and Connors.17 Excess drug (25 mg) was added to 15 mL of ... Phase-solubility techniques. In: Reilly CN, ed. Advances in ...